Cognitive dysfunction in central disorders of hypersomnolence: A systematic review

Central disorders of hypersomnolence (CDH) are characterized by excessive daytime sleepiness not related to comorbid sleep or medical disturbances. We systematically examined scientific literature on cognitive functions in patients suffering from CDH. Forty-eight studies proved eligible and were analyzed separately for Narcolepsy Type 1 (NT1), 2 (NT2), Idiopathic hypersomnia (IH) Kleine-Levin syndrome (KLS). Results grouped into the domains attention, memory, executive higher order cognition. Consistent attention impairments emerged NT1, NT2 IH patients, with NT1 showing most compromised profile. Memory largely unimpaired CDH except KLS who display memory deficit. Executive higher-order cognition have been assessed while they received little-to-no other high performance but exhibit a complex pattern impairment cognition, poor decision-making impaired emotional processing. Moreover, show increased creative abilities. Assessing monitoring experienced will allow design personalized interventions, parallel pharmacological treatment, aimed at improving functioning quality life these patients.